Abstract: Under the background of the continuous cooling of characteristic towns, the pace of industrial restructuring has been accelerated in all regions. It has become an urgent task to select and cultivate the advantageous industries which are not only suitable for the base of economic development as well as the transformation and upgrading of industrial structure, but also have development potential. This paper selects characteristic e-commerce towns with large number of small and medium-sized e-commerce enterprises as the research objects. By mining the evaluation and selection methods of enterprise big data research on the dominant industries in towns, this paper explores a method based on the universality of big data, hoping to provide beneficial thinking for similar towns.