Abstract: The outbreak of the COVID-19 provided a new perspective for thinking about the relationship between urban and rural areas. China's long-standing urban-rural dual structure made rural areas show relative advantages in epidemic prevention at this time. Therefore, from the perspective of public health, based on the background of territorial space planning and rural revitalization strategy, this paper re-examined the relationship between urban and rural areas and proposed to convert the environmental advantages of the two in daily life and epidemic period, so as to promote the flow of urban and rural factors and improve the public health level of the two. Then, based on the production-living-ecology spaces, this paper explored the possibility of urban and rural interaction of industrial reciprocity, function conversion and ecological integration from the perspective of public health. Based on the three interaction modes, with the premise of policy system optimization and the support of transportation system, the planning strategies were implemented to build the interactive healthy city between urban and rural areas that can help form a two-way value chain that promotes urban-rural complementarity and improves the public health level of urban and rural areas, and provide a theoretical model for the construction of a new healthy city in the post-COVID-19 era in the context of territorial spatial planning.