Abstract: In the context of high-quality development, delineating industrial sector blocks is key to safeguarding industrial space and promoting intensive development. This study focuses on Zengcheng District, Guangzhou City, Guangdong Province, and addresses its core issues concerning industrial land, such as 'fragmented layout, inefficient utilization, and irrational industrial structure'. Based on city-level policy frameworks, including the Guangzhou industrial cluster management measures, and with the objectives of 'maintaining quantity, enhancing quality, and increasing efficiency', it establishes a closed-loop mechanism for delineating industrial sector blocks through 'total volume locking-industrial guidance-classification and grading-performance evaluation-boundary optimization-dynamic assessment'. After optimization, the purity of industrial land has been significantly improved, effectively supporting the agglomeration of strategic industries such as new energy vehicles. This study provides a practical and operable paradigm for similar regions to resolve the paradox of industrial space governance and promote the upgrading of industrial space.